Institute of Medical Biology, A*STAR
Brian Burke received his Ph.D. from Imperial College of the University of London where he carried out investigations into the molecular structure of human erythrocyte spectrin. This was followed by postdoctoral work with Graham Warren at the EMBL in Heidelberg and with Larry Gerace at Johns Hopkins University in Baltimore, Maryland. During this period he developed a longstanding interest in the structure and function of the nuclear envelope.
After a period as staff scientist at the EMBL, Dr. Burke joined the faculty of Harvard Medical School in the Department of Cell Biology. He later served as Professor of Cell Biology and Anatomy at the University of Calgary and as the Haskell Hess Professor of Cell Biology at the University of Florida College of Medicine. Since August 2009, Dr. Burke has been a Principal Investigator at the IMB.
Dr. Burke’s research focus now concerns the mechanisms by which defects in genes encoding nuclear envelope proteins, including human A-type lamins, give rise to a variety of human diseases. These include forms of muscular dystrophy, lipodystrophy and Hutchinson-Gilford progeria, a premature aging syndrome.